Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells

المؤلفون المشاركون

Slevin, Mark
Fang, Wen-Hui
Kumar, Shant
McDowell, Garry
Smith, David
Olah, Peter
Al-Baradie, Raid Saleem
Al-Rukban, Mohammad Othman
Petcu, Eugene Bogdan
Krupinski, Jerzy

المصدر

Stem Cells International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-08-29

دولة النشر

مصر

عدد الصفحات

10

الملخص EN

The potential use of stem cells as therapeutics in disease has gained momentum over the last few years and recently phase-I clinical trials have shown favourable results in treatment of a small cohort of acute stroke patients.

Similarly, they have been used in preclinical models drug-loaded for the effective treatment of solid tumours.

Here we have characterized uptake and release of a novel p5-cyclin-dependent kinase 5 (CDK5) inhibitory peptide by mesenchymal stem cells and showed release levels capable of blocking aberrant cyclin-dependent kinase 5 (CDK5) signaling pathways, through phosphorylation of cyclin-dependent kinase 5 (CDK5) and p53.

These pathways represent the major acute mechanism stimulating apoptosis after stroke and hence its modulation could benefit patient recovery.

This work indicates a potential use for drug-loaded stem cells as delivery vehicles for stroke therapeutics and in addition as anticancer receptacles particularly, if a targeting and/or holding mechanism can be defined.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Fang, Wen-Hui& Kumar, Shant& McDowell, Garry& Smith, David& Krupinski, Jerzy& Olah, Peter…[et al.]. 2016. Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116200

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fang, Wen-Hui…[et al.]. Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116200

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Fang, Wen-Hui& Kumar, Shant& McDowell, Garry& Smith, David& Krupinski, Jerzy& Olah, Peter…[et al.]. Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116200

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1116200