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Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells
Joint Authors
Slevin, Mark
Fang, Wen-Hui
Kumar, Shant
McDowell, Garry
Smith, David
Olah, Peter
Al-Baradie, Raid Saleem
Al-Rukban, Mohammad Othman
Petcu, Eugene Bogdan
Krupinski, Jerzy
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
10
Abstract EN
The potential use of stem cells as therapeutics in disease has gained momentum over the last few years and recently phase-I clinical trials have shown favourable results in treatment of a small cohort of acute stroke patients.
Similarly, they have been used in preclinical models drug-loaded for the effective treatment of solid tumours.
Here we have characterized uptake and release of a novel p5-cyclin-dependent kinase 5 (CDK5) inhibitory peptide by mesenchymal stem cells and showed release levels capable of blocking aberrant cyclin-dependent kinase 5 (CDK5) signaling pathways, through phosphorylation of cyclin-dependent kinase 5 (CDK5) and p53.
These pathways represent the major acute mechanism stimulating apoptosis after stroke and hence its modulation could benefit patient recovery.
This work indicates a potential use for drug-loaded stem cells as delivery vehicles for stroke therapeutics and in addition as anticancer receptacles particularly, if a targeting and/or holding mechanism can be defined.
American Psychological Association (APA)
Fang, Wen-Hui& Kumar, Shant& McDowell, Garry& Smith, David& Krupinski, Jerzy& Olah, Peter…[et al.]. 2016. Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116200
Modern Language Association (MLA)
Fang, Wen-Hui…[et al.]. Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116200
American Medical Association (AMA)
Fang, Wen-Hui& Kumar, Shant& McDowell, Garry& Smith, David& Krupinski, Jerzy& Olah, Peter…[et al.]. Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116200