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Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis
المؤلفون المشاركون
Liu, Hui
Zhang, Shaoli
Zhao, Lihua
Zhang, Yan
Li, Qiuping
Chai, Xiaoyan
Zhang, Yongchun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Resveratrol (trans-3,5,4′-trihydroxystilbene) (RSV) is a natural polyphenol with protective effects over cardiac tissues and can affect cell survival and differentiation in cardiac stem cells transplantation.
However, whether this agent can affect cardiomyocytes (CMs) differentiation of induced pluripotent stem cells (iPSCs) is not yet clear.
This study explored whether RSV can affect CMs differentiation of human iPSCs.
Under embryoid bodies (EBs) condition, the effect of RSV on the change of pluripotent markers, endoderm markers, mesoderm markers, and ectoderm markers was measured using qRT-PCR.
Under CM differentiation culture, the effect of RSV on CM specific markers was also measured.
The regulative role of RSV over canonical Wnt signal pathway and serum response factor- (SRF-) miR-1 axis and the functions of these two axes were further studied.
Results showed that RSV had no effect on the self-renewal of human iPSCs but could promote mesoderm differentiation.
Under CM differentiation culture, RSV could promote CM differentiation of human iPSCs through suppressing canonical Wnt signal pathway and enhancing SRF-miR-1 axis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Hui& Zhang, Shaoli& Zhao, Lihua& Zhang, Yan& Li, Qiuping& Chai, Xiaoyan…[et al.]. 2015. Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116240
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Hui…[et al.]. Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116240
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Hui& Zhang, Shaoli& Zhao, Lihua& Zhang, Yan& Li, Qiuping& Chai, Xiaoyan…[et al.]. Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116240
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116240
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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