Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis
Joint Authors
Liu, Hui
Zhang, Shaoli
Zhao, Lihua
Zhang, Yan
Li, Qiuping
Chai, Xiaoyan
Zhang, Yongchun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Resveratrol (trans-3,5,4′-trihydroxystilbene) (RSV) is a natural polyphenol with protective effects over cardiac tissues and can affect cell survival and differentiation in cardiac stem cells transplantation.
However, whether this agent can affect cardiomyocytes (CMs) differentiation of induced pluripotent stem cells (iPSCs) is not yet clear.
This study explored whether RSV can affect CMs differentiation of human iPSCs.
Under embryoid bodies (EBs) condition, the effect of RSV on the change of pluripotent markers, endoderm markers, mesoderm markers, and ectoderm markers was measured using qRT-PCR.
Under CM differentiation culture, the effect of RSV on CM specific markers was also measured.
The regulative role of RSV over canonical Wnt signal pathway and serum response factor- (SRF-) miR-1 axis and the functions of these two axes were further studied.
Results showed that RSV had no effect on the self-renewal of human iPSCs but could promote mesoderm differentiation.
Under CM differentiation culture, RSV could promote CM differentiation of human iPSCs through suppressing canonical Wnt signal pathway and enhancing SRF-miR-1 axis.
American Psychological Association (APA)
Liu, Hui& Zhang, Shaoli& Zhao, Lihua& Zhang, Yan& Li, Qiuping& Chai, Xiaoyan…[et al.]. 2015. Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116240
Modern Language Association (MLA)
Liu, Hui…[et al.]. Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116240
American Medical Association (AMA)
Liu, Hui& Zhang, Shaoli& Zhao, Lihua& Zhang, Yan& Li, Qiuping& Chai, Xiaoyan…[et al.]. Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116240