Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy

المؤلفون المشاركون

Ren, Huaijuan
Sang, Yunxia
Zhang, Fengli
Liu, Zhaoqing
Qi, Nianmin
Chen, Yantian

المصدر

Stem Cells International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-01-10

دولة النشر

مصر

عدد الصفحات

13

الملخص EN

Although mesenchymal stem cells (MSCs) based therapy has been considered as a promising tool for tissue repair and regeneration, the optimal cell source remains unknown.

Umbilical cord (UC), dental pulp (DP), and menstrual blood (MB) are easily accessible sources, which make them attractive candidates for MSCs.

The goal of this study was to compare the biological characteristics, including morphology, proliferation, antiapoptosis, multilineage differentiation capacity, and immunophenotype of UC-, DP-, and MB-MSCs in order to provide a theoretical basis for clinical selection and application of these cells.

As a result, all UC-, DP-, and MB-MSCs have self-renewal capacity and multipotentiality.

However, the UC-MSCs seemed to have higher cell proliferation ability, while DP-MSCs may have significant advantages for osteogenic differentiation, lower cell apoptosis, and senescence.

These differences may be associated with the different expression level of cytokines, including vascular endothelial growth factor, fibroblast growth factor, keratinocyte growth factor, and hepatocyte growth factor in each of the MSCs.

Comprehensively, our results suggest DP-MSCs may be a desired source for clinical applications of cell therapy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ren, Huaijuan& Sang, Yunxia& Zhang, Fengli& Liu, Zhaoqing& Qi, Nianmin& Chen, Yantian. 2016. Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116388

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ren, Huaijuan…[et al.]. Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116388

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ren, Huaijuan& Sang, Yunxia& Zhang, Fengli& Liu, Zhaoqing& Qi, Nianmin& Chen, Yantian. Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116388

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1116388