Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy
Joint Authors
Ren, Huaijuan
Sang, Yunxia
Zhang, Fengli
Liu, Zhaoqing
Qi, Nianmin
Chen, Yantian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Although mesenchymal stem cells (MSCs) based therapy has been considered as a promising tool for tissue repair and regeneration, the optimal cell source remains unknown.
Umbilical cord (UC), dental pulp (DP), and menstrual blood (MB) are easily accessible sources, which make them attractive candidates for MSCs.
The goal of this study was to compare the biological characteristics, including morphology, proliferation, antiapoptosis, multilineage differentiation capacity, and immunophenotype of UC-, DP-, and MB-MSCs in order to provide a theoretical basis for clinical selection and application of these cells.
As a result, all UC-, DP-, and MB-MSCs have self-renewal capacity and multipotentiality.
However, the UC-MSCs seemed to have higher cell proliferation ability, while DP-MSCs may have significant advantages for osteogenic differentiation, lower cell apoptosis, and senescence.
These differences may be associated with the different expression level of cytokines, including vascular endothelial growth factor, fibroblast growth factor, keratinocyte growth factor, and hepatocyte growth factor in each of the MSCs.
Comprehensively, our results suggest DP-MSCs may be a desired source for clinical applications of cell therapy.
American Psychological Association (APA)
Ren, Huaijuan& Sang, Yunxia& Zhang, Fengli& Liu, Zhaoqing& Qi, Nianmin& Chen, Yantian. 2016. Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116388
Modern Language Association (MLA)
Ren, Huaijuan…[et al.]. Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116388
American Medical Association (AMA)
Ren, Huaijuan& Sang, Yunxia& Zhang, Fengli& Liu, Zhaoqing& Qi, Nianmin& Chen, Yantian. Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116388