Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies
المؤلفون المشاركون
Baldini, Nicola
Garcia-Castro, Javier
Abarrategi, Ander
Tornin, Juan
Martinez-Cruzado, Lucia
Hamilton, Ashley
Martinez-Campos, Enrique
Rodrigo, Juan P.
González, M. Victoria
Rodriguez, Rene
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-05
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.
Although standard chemotherapy has significantly improved long-term survival over the past few decades, the outcome for those patients with metastatic or recurrent OS remains dismally poor and, therefore, novel agents and treatment regimens are urgently required.
A hypothesis to explain the resistance of OS to chemotherapy is the existence of drug resistant CSCs with progenitor properties that are responsible of tumor relapses and metastasis.
These subpopulations of CSCs commonly emerge during tumor evolution from the cell-of-origin, which are the normal cells that acquire the first cancer-promoting mutations to initiate tumor formation.
In OS, several cell types along the osteogenic lineage have been proposed as cell-of-origin.
Both the cell-of-origin and their derived CSC subpopulations are highly influenced by environmental and epigenetic factors and, therefore, targeting the OS-CSC environment and niche is the rationale for many recently postulated therapies.
Likewise, some strategies for targeting CSC-associated signaling pathways have already been tested in both preclinical and clinical settings.
This review recapitulates current OS cell-of-origin models, the properties of the OS-CSC and its niche, and potential new therapies able to target OS-CSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abarrategi, Ander& Tornin, Juan& Martinez-Cruzado, Lucia& Hamilton, Ashley& Martinez-Campos, Enrique& Rodrigo, Juan P.…[et al.]. 2016. Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abarrategi, Ander…[et al.]. Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abarrategi, Ander& Tornin, Juan& Martinez-Cruzado, Lucia& Hamilton, Ashley& Martinez-Campos, Enrique& Rodrigo, Juan P.…[et al.]. Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر