Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies

Joint Authors

Baldini, Nicola
Garcia-Castro, Javier
Abarrategi, Ander
Tornin, Juan
Martinez-Cruzado, Lucia
Hamilton, Ashley
Martinez-Campos, Enrique
Rodrigo, Juan P.
González, M. Victoria
Rodriguez, Rene

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-06-05

Country of Publication

Egypt

No. of Pages

13

Abstract EN

Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.

Although standard chemotherapy has significantly improved long-term survival over the past few decades, the outcome for those patients with metastatic or recurrent OS remains dismally poor and, therefore, novel agents and treatment regimens are urgently required.

A hypothesis to explain the resistance of OS to chemotherapy is the existence of drug resistant CSCs with progenitor properties that are responsible of tumor relapses and metastasis.

These subpopulations of CSCs commonly emerge during tumor evolution from the cell-of-origin, which are the normal cells that acquire the first cancer-promoting mutations to initiate tumor formation.

In OS, several cell types along the osteogenic lineage have been proposed as cell-of-origin.

Both the cell-of-origin and their derived CSC subpopulations are highly influenced by environmental and epigenetic factors and, therefore, targeting the OS-CSC environment and niche is the rationale for many recently postulated therapies.

Likewise, some strategies for targeting CSC-associated signaling pathways have already been tested in both preclinical and clinical settings.

This review recapitulates current OS cell-of-origin models, the properties of the OS-CSC and its niche, and potential new therapies able to target OS-CSCs.

American Psychological Association (APA)

Abarrategi, Ander& Tornin, Juan& Martinez-Cruzado, Lucia& Hamilton, Ashley& Martinez-Campos, Enrique& Rodrigo, Juan P.…[et al.]. 2016. Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116408

Modern Language Association (MLA)

Abarrategi, Ander…[et al.]. Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116408

American Medical Association (AMA)

Abarrategi, Ander& Tornin, Juan& Martinez-Cruzado, Lucia& Hamilton, Ashley& Martinez-Campos, Enrique& Rodrigo, Juan P.…[et al.]. Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116408

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1116408