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In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging
المؤلفون المشاركون
Song, MeiJuan
Lv, Qi
Cao, Juan
Sun, ShuLi
Xiao, PeiXin
Hou, ShiKe
Ding, Hui
Liu, ZiQuan
Wang, Xue
Sun, ZhiGuang
Fan, HaoJun
Qin, Xiaojing
Yu, Mengyang
Liu, Jinyang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-17
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Recently, mesenchymal stem cells (MSCs) are increasingly used as a panacea for multiple types of disease short of effective treatment.
Dozens of clinical trials published demonstrated strikingly positive therapeutic effects of MSCs.
However, as a specific agent, little research has focused on the dynamic distribution of MSCs after in vivo administration.
In this study, we track systemically transplanted allogeneic bone marrow mesenchymal stem cells (BMSCs) in normal rats through bioluminescence imaging (BLI) in real time.
Ex vivo organ imaging, immunohistochemistry (IHC), and RT-PCR were conducted to verify the histological distribution of BMSCs.
Our results showed that BMSCs home to the dorsal skin apart from the lungs and kidneys after tail vein injection and could not be detected 14 days later.
Allogeneic BMSCs mainly appeared not at the parenchymatous organs but at the subepidermal connective tissue and adipose tissue in healthy rats.
There were no significant MSCs-related adverse effects except for transient decrease in neutrophils.
These findings will provide experimental evidences for a better understanding of the biocharacteristics of BMSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Juan& Hou, ShiKe& Ding, Hui& Liu, ZiQuan& Song, MeiJuan& Qin, Xiaojing…[et al.]. 2016. In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116467
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Juan…[et al.]. In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116467
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Juan& Hou, ShiKe& Ding, Hui& Liu, ZiQuan& Song, MeiJuan& Qin, Xiaojing…[et al.]. In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116467
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116467
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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