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In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging
Joint Authors
Song, MeiJuan
Lv, Qi
Cao, Juan
Sun, ShuLi
Xiao, PeiXin
Hou, ShiKe
Ding, Hui
Liu, ZiQuan
Wang, Xue
Sun, ZhiGuang
Fan, HaoJun
Qin, Xiaojing
Yu, Mengyang
Liu, Jinyang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Recently, mesenchymal stem cells (MSCs) are increasingly used as a panacea for multiple types of disease short of effective treatment.
Dozens of clinical trials published demonstrated strikingly positive therapeutic effects of MSCs.
However, as a specific agent, little research has focused on the dynamic distribution of MSCs after in vivo administration.
In this study, we track systemically transplanted allogeneic bone marrow mesenchymal stem cells (BMSCs) in normal rats through bioluminescence imaging (BLI) in real time.
Ex vivo organ imaging, immunohistochemistry (IHC), and RT-PCR were conducted to verify the histological distribution of BMSCs.
Our results showed that BMSCs home to the dorsal skin apart from the lungs and kidneys after tail vein injection and could not be detected 14 days later.
Allogeneic BMSCs mainly appeared not at the parenchymatous organs but at the subepidermal connective tissue and adipose tissue in healthy rats.
There were no significant MSCs-related adverse effects except for transient decrease in neutrophils.
These findings will provide experimental evidences for a better understanding of the biocharacteristics of BMSCs.
American Psychological Association (APA)
Cao, Juan& Hou, ShiKe& Ding, Hui& Liu, ZiQuan& Song, MeiJuan& Qin, Xiaojing…[et al.]. 2016. In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116467
Modern Language Association (MLA)
Cao, Juan…[et al.]. In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116467
American Medical Association (AMA)
Cao, Juan& Hou, ShiKe& Ding, Hui& Liu, ZiQuan& Song, MeiJuan& Qin, Xiaojing…[et al.]. In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116467