tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis
المؤلفون المشاركون
Sun, Cheuk-Kwan
Leu, Steve
Day, Yuan-Ji
Yip, Hon-Kan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-16
دولة النشر
مصر
عدد الصفحات
23
الملخص EN
We examined the role of tissue plasminogen activator- (tPA-) matrix metalloproteinase- (MMP-) 9 in mobilizing endothelial progenitor cells (EPCs) from bone marrow to circulation and critical limb ischemia (CLI) region.
Male C57BL/6J mice having been irradiated were categorized into wild-type mice (WT) receiving WT bone marrow cell (BMC) transfusion (group 1), WT mice receiving MMP-9 knockout (MMP-9−/−) BMC (group 2), MMP-9−/− receiving MMP-9−/− BMC (group 3), and MMP-9−/− receiving WT BMC (group 4), each of which was subdivided into sham control (SC), CLI, SC-tPA, and CLI-tPA.
In groups 1 and 4, by post-CLI 18 h and day 14, circulating EPC (C-kit+/CD31+, Sca-1+/KDR+) levels were highest in CLI-tPA subgroup.
In groups 2 and 3, EPC levels did not differ among all subgroups.
The EPC levels in bone marrow were higher in groups 2 and 3 than those in groups 1 and 4.
By day 14, in animals with CLI, expression levels of proangiogenic factors (CXCR4, SDF-1α, and VEGF) showed similar trends as circulating EPC levels.
Moreover, the number of infiltrated neutrophils and macrophages in quadriceps was higher in groups 1 and 4 than groups in 2 and 3.
In conclusion, tPA-MMP-9 axis plays a crucial role in EPC mobilization and angiogenesis in experimental CLI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leu, Steve& Day, Yuan-Ji& Sun, Cheuk-Kwan& Yip, Hon-Kan. 2016. tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis. Stem Cells International،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1116758
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leu, Steve…[et al.]. tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-23.
https://search.emarefa.net/detail/BIM-1116758
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leu, Steve& Day, Yuan-Ji& Sun, Cheuk-Kwan& Yip, Hon-Kan. tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1116758
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116758
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر