Repair Injured Heart by Regulating Cardiac Regenerative Signals
المؤلفون المشاركون
Wang, Yigang
Cai, Wenfeng
Paul, Christian
Liu, Guan-Sheng
Wang, Lei
Wen, Zhi-Li
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-09
دولة النشر
مصر
عدد الصفحات
17
الملخص EN
Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis.
Unfortunately, while high-quality regeneration can be performed in amphibians and zebrafish hearts, mammalian hearts do not respond in kind.
Indeed, a long-term loss of proliferative capacity in mammalian adult cardiomyocytes in combination with dysregulated induction of tissue fibrosis impairs mammalian endogenous heart regenerative capacity, leading to deleterious cardiac remodeling at the end stage of heart failure.
Interestingly, several studies have demonstrated that cardiomyocyte proliferation capacity is retained in mammals very soon after birth, and cardiac regeneration potential is correspondingly preserved in some preadolescent vertebrates after myocardial infarction.
There is therefore great interest in uncovering the molecular mechanisms that may allow heart regeneration during adult stages.
This review will summarize recent findings on cardiac regenerative regulatory mechanisms, especially with respect to extracellular signals and intracellular pathways that may provide novel therapeutics for heart diseases.
Particularly, both in vitro and in vivo experimental evidences will be presented to highlight the functional role of these signaling cascades in regulating cardiomyocyte proliferation, cardiomyocyte growth, and maturation, with special emphasis on their responses to heart tissue injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Wenfeng& Liu, Guan-Sheng& Wang, Lei& Paul, Christian& Wen, Zhi-Li& Wang, Yigang. 2016. Repair Injured Heart by Regulating Cardiac Regenerative Signals. Stem Cells International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116890
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Wenfeng…[et al.]. Repair Injured Heart by Regulating Cardiac Regenerative Signals. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1116890
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Wenfeng& Liu, Guan-Sheng& Wang, Lei& Paul, Christian& Wen, Zhi-Li& Wang, Yigang. Repair Injured Heart by Regulating Cardiac Regenerative Signals. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116890
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116890
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر