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Repair Injured Heart by Regulating Cardiac Regenerative Signals
Joint Authors
Wang, Yigang
Cai, Wenfeng
Paul, Christian
Liu, Guan-Sheng
Wang, Lei
Wen, Zhi-Li
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-09
Country of Publication
Egypt
No. of Pages
17
Abstract EN
Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis.
Unfortunately, while high-quality regeneration can be performed in amphibians and zebrafish hearts, mammalian hearts do not respond in kind.
Indeed, a long-term loss of proliferative capacity in mammalian adult cardiomyocytes in combination with dysregulated induction of tissue fibrosis impairs mammalian endogenous heart regenerative capacity, leading to deleterious cardiac remodeling at the end stage of heart failure.
Interestingly, several studies have demonstrated that cardiomyocyte proliferation capacity is retained in mammals very soon after birth, and cardiac regeneration potential is correspondingly preserved in some preadolescent vertebrates after myocardial infarction.
There is therefore great interest in uncovering the molecular mechanisms that may allow heart regeneration during adult stages.
This review will summarize recent findings on cardiac regenerative regulatory mechanisms, especially with respect to extracellular signals and intracellular pathways that may provide novel therapeutics for heart diseases.
Particularly, both in vitro and in vivo experimental evidences will be presented to highlight the functional role of these signaling cascades in regulating cardiomyocyte proliferation, cardiomyocyte growth, and maturation, with special emphasis on their responses to heart tissue injury.
American Psychological Association (APA)
Cai, Wenfeng& Liu, Guan-Sheng& Wang, Lei& Paul, Christian& Wen, Zhi-Li& Wang, Yigang. 2016. Repair Injured Heart by Regulating Cardiac Regenerative Signals. Stem Cells International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116890
Modern Language Association (MLA)
Cai, Wenfeng…[et al.]. Repair Injured Heart by Regulating Cardiac Regenerative Signals. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1116890
American Medical Association (AMA)
Cai, Wenfeng& Liu, Guan-Sheng& Wang, Lei& Paul, Christian& Wen, Zhi-Li& Wang, Yigang. Repair Injured Heart by Regulating Cardiac Regenerative Signals. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116890