Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms
المؤلفون المشاركون
Du, Jie
Li, Haiyang
Lan, Feng
Jiang, Wenjian
Ren, Weihong
Guo, Dong
Guo, Jialong
Wang, Xiaolong
Liu, Yuyong
Zhang, Hongjia
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-20
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Previous studies indicate that extracellular matrix (ECM) disorders lead to the apoptosis of Vascular Smooth Muscle Cells (VSMCs), which impairs the aortic wall by reducing the generation of elastic fibers, and ultimately result in ascending aortic aneurysm.
The critical role of the Yes-associated protein (YAP) has been elucidated in cardiac/SMC proliferation during cardiovascular development.
However, the association of YAP expression and extracellular matrix disorders in ascending aortic aneurysms is not clear.
Here, we present for the first time that the downregulation of YAP in VSMCs is associated with ECM disorders of the media in ascending aortic aneurysms.
We found that aortic ECM deteriorated with increased apoptotic VSMCs.
Moreover, expression of YAP was dramatically reduced in the aortic walls of patients with ascending aortic aneurysms, while the normal aortic samples exhibited abundant YAP in the VSMCs.
These results suggest that downregulation of YAP leads to apoptosis of VSMCs, which are essential for the homeostasis of the aortic wall.
The resultant ECM disorders affect aortic structure and function and contribute to the development of ascending aortic aneurysms.
In summary, through assessment of clinical samples, we revealed the association between downregulation of YAP in VSMCs and the development of ascending aortic aneurysms, providing new insight into the pathogenesis of this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Haiyang& Jiang, Wenjian& Ren, Weihong& Guo, Dong& Guo, Jialong& Wang, Xiaolong…[et al.]. 2016. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116969
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Haiyang…[et al.]. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116969
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Haiyang& Jiang, Wenjian& Ren, Weihong& Guo, Dong& Guo, Jialong& Wang, Xiaolong…[et al.]. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116969
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116969
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر