Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms

Joint Authors

Du, Jie
Li, Haiyang
Lan, Feng
Jiang, Wenjian
Ren, Weihong
Guo, Dong
Guo, Jialong
Wang, Xiaolong
Liu, Yuyong
Zhang, Hongjia

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-01-20

Country of Publication

Egypt

No. of Pages

8

Abstract EN

Previous studies indicate that extracellular matrix (ECM) disorders lead to the apoptosis of Vascular Smooth Muscle Cells (VSMCs), which impairs the aortic wall by reducing the generation of elastic fibers, and ultimately result in ascending aortic aneurysm.

The critical role of the Yes-associated protein (YAP) has been elucidated in cardiac/SMC proliferation during cardiovascular development.

However, the association of YAP expression and extracellular matrix disorders in ascending aortic aneurysms is not clear.

Here, we present for the first time that the downregulation of YAP in VSMCs is associated with ECM disorders of the media in ascending aortic aneurysms.

We found that aortic ECM deteriorated with increased apoptotic VSMCs.

Moreover, expression of YAP was dramatically reduced in the aortic walls of patients with ascending aortic aneurysms, while the normal aortic samples exhibited abundant YAP in the VSMCs.

These results suggest that downregulation of YAP leads to apoptosis of VSMCs, which are essential for the homeostasis of the aortic wall.

The resultant ECM disorders affect aortic structure and function and contribute to the development of ascending aortic aneurysms.

In summary, through assessment of clinical samples, we revealed the association between downregulation of YAP in VSMCs and the development of ascending aortic aneurysms, providing new insight into the pathogenesis of this disease.

American Psychological Association (APA)

Li, Haiyang& Jiang, Wenjian& Ren, Weihong& Guo, Dong& Guo, Jialong& Wang, Xiaolong…[et al.]. 2016. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116969

Modern Language Association (MLA)

Li, Haiyang…[et al.]. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116969

American Medical Association (AMA)

Li, Haiyang& Jiang, Wenjian& Ren, Weihong& Guo, Dong& Guo, Jialong& Wang, Xiaolong…[et al.]. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116969

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1116969