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Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats
المؤلفون المشاركون
Li, Zhaoshen
Zhao, Hang
He, Zhiying
Huang, Dandan
Gao, Jun
Gong, Yanfang
Wu, Hongyu
Xu, Aifang
Meng, Xiangjun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-18
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Background & Aims.
Severe acute pancreatitis (SAP) remains a high-mortality disease.
Bone marrow (BM) mesenchymal stem cells (MSCs) have been demonstrated to have plasticity of transdifferentiation and to have immunomodulatory functions.
In the present study, we assessed the roles of MSCs in SAP and the therapeutic effects of MSC on SAP after transplantation.
Methods.
A pancreatitis rat model was induced by the injection of taurocholic acid (TCA) into the pancreatic duct.
After isolation and characterization of MSC from BM, MSC transplantation was conducted 24 hrs after SAP induction by tail vein injection.
The survival rate was observed and MSCs were traced after transplantation.
The expression of TNF-α and IL-1β mRNA in the transplantation group was also analyzed.
Results.
The survival rate of the transplantation group was significantly higher compared to the control group (p<0.05).
Infused MSCs were detected in the pancreas and BM 3 days after transplantation.
The expression of TNF-α and IL-1β mRNA in the transplantation group was significantly lower than in the control group in both the pancreas and the lungs (p<0.05).
Conclusions.
MSC transplantation could improve the prognosis of SAP rats.
Engrafted MSCs have the capacity of homing, migration, and planting during the treatment of SAP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Hang& He, Zhiying& Huang, Dandan& Gao, Jun& Gong, Yanfang& Wu, Hongyu…[et al.]. 2016. Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117065
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Hang…[et al.]. Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117065
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Hang& He, Zhiying& Huang, Dandan& Gao, Jun& Gong, Yanfang& Wu, Hongyu…[et al.]. Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117065
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117065
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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