Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats
Joint Authors
Li, Zhaoshen
Zhao, Hang
He, Zhiying
Huang, Dandan
Gao, Jun
Gong, Yanfang
Wu, Hongyu
Xu, Aifang
Meng, Xiangjun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-18
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Background & Aims.
Severe acute pancreatitis (SAP) remains a high-mortality disease.
Bone marrow (BM) mesenchymal stem cells (MSCs) have been demonstrated to have plasticity of transdifferentiation and to have immunomodulatory functions.
In the present study, we assessed the roles of MSCs in SAP and the therapeutic effects of MSC on SAP after transplantation.
Methods.
A pancreatitis rat model was induced by the injection of taurocholic acid (TCA) into the pancreatic duct.
After isolation and characterization of MSC from BM, MSC transplantation was conducted 24 hrs after SAP induction by tail vein injection.
The survival rate was observed and MSCs were traced after transplantation.
The expression of TNF-α and IL-1β mRNA in the transplantation group was also analyzed.
Results.
The survival rate of the transplantation group was significantly higher compared to the control group (p<0.05).
Infused MSCs were detected in the pancreas and BM 3 days after transplantation.
The expression of TNF-α and IL-1β mRNA in the transplantation group was significantly lower than in the control group in both the pancreas and the lungs (p<0.05).
Conclusions.
MSC transplantation could improve the prognosis of SAP rats.
Engrafted MSCs have the capacity of homing, migration, and planting during the treatment of SAP.
American Psychological Association (APA)
Zhao, Hang& He, Zhiying& Huang, Dandan& Gao, Jun& Gong, Yanfang& Wu, Hongyu…[et al.]. 2016. Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117065
Modern Language Association (MLA)
Zhao, Hang…[et al.]. Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117065
American Medical Association (AMA)
Zhao, Hang& He, Zhiying& Huang, Dandan& Gao, Jun& Gong, Yanfang& Wu, Hongyu…[et al.]. Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117065