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Acute Hypoxic Stress Affects Migration Machinery of Tissue O2-Adapted Adipose Stromal Cells
المؤلفون المشاركون
Buravkova, Ludmila B.
Udartseva, Olga O.
Lobanova, Margarita V.
Andreeva, Elena R.
Buravkov, Sergey V.
Ogneva, I. V.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-28
دولة النشر
مصر
عدد الصفحات
16
الملخص EN
The ability of mesenchymal stromal (stem) cells (MSCs) to be mobilised from their local depot towards sites of injury and to participate in tissue repair makes these cells promising candidates for cell therapy.
Physiological O2 tension in an MSC niche in vivo is about 4–7%.
However, most in vitro studies of MSC functional activity are performed at 20% O2.
Therefore, this study focused on the effects of short-term hypoxic stress (0.1% O2, 24 h) on adipose tissue-derived MSC motility at tissue-related O2 level.
No significant changes in integrin expression were detected after short-term hypoxic stress.
However, O2 deprivation provoked vimentin disassembly and actin polymerisation and increased cell stiffness.
In addition, hypoxic stress induced the downregulation of ACTR3, DSTN, MACF1, MID1, MYPT1, NCK1, ROCK1, TIAM1, and WASF1 expression, the products of which are known to be involved in leading edge formation and cell translocation.
These changes were accompanied by the attenuation of targeted and nontargeted migration of MSCs after short-term hypoxic exposure, as demonstrated in scratch and transwell migration assays.
These results indicate that acute hypoxic stress can modulate MSC function in their native milieu, preventing their mobilisation from sites of injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Udartseva, Olga O.& Lobanova, Margarita V.& Andreeva, Elena R.& Buravkov, Sergey V.& Ogneva, I. V.& Buravkova, Ludmila B.. 2016. Acute Hypoxic Stress Affects Migration Machinery of Tissue O2-Adapted Adipose Stromal Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117087
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Udartseva, Olga O.…[et al.]. Acute Hypoxic Stress Affects Migration Machinery of Tissue O2-Adapted Adipose Stromal Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1117087
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Udartseva, Olga O.& Lobanova, Margarita V.& Andreeva, Elena R.& Buravkov, Sergey V.& Ogneva, I. V.& Buravkova, Ludmila B.. Acute Hypoxic Stress Affects Migration Machinery of Tissue O2-Adapted Adipose Stromal Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117087
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117087
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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