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Comparison of Osteogenesis between Adipose-Derived Mesenchymal Stem Cells and Their Sheets on Poly-ε-Caprolactoneβ-Tricalcium Phosphate Composite Scaffolds in Canine Bone Defects
المؤلفون المشاركون
Kim, Yongsun
Lee, Seung Hoon
Kang, Byung-jae
Kim, Wan Hee
Yun, Hui-suk
Kweon, Oh-kyeong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-16
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Multipotent mesenchymal stem cells (MSCs) and MSC sheets have effective potentials of bone regeneration.
Composite polymer/ceramic scaffolds such as poly-ε-caprolactone (PCL)/β-tricalcium phosphate (β-TCP) are widely used to repair large bone defects.
The present study investigated the in vitro osteogenic potential of canine adipose-derived MSCs (Ad-MSCs) and Ad-MSC sheets.
Composite PCL/β-TCP scaffolds seeded with Ad-MSCs or wrapped with osteogenic Ad-MSC sheets (OCS) were also fabricated and their osteogenic potential was assessed following transplantation into critical-sized bone defects in dogs.
The alkaline phosphatase (ALP) activity of osteogenic Ad-MSCs (O-MSCs) and OCS was significantly higher than that of undifferentiated Ad-MSCs (U-MSCs).
The ALP, runt-related transcription factor 2, osteopontin, and bone morphogenetic protein 7 mRNA levels were upregulated in O-MSCs and OCS as compared to U-MSCs.
In a segmental bone defect, the amount of newly formed bone was greater in PCL/β-TCP/OCS and PCL/β-TCP/O-MSCs/OCS than in the other groups.
The OCS exhibit strong osteogenic capacity, and OCS combined with a PCL/β-TCP composite scaffold stimulated new bone formation in a critical-sized bone defect.
These results suggest that the PCL/β-TCP/OCS composite has potential clinical applications in bone regeneration and can be used as an alternative treatment modality in bone tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Yongsun& Lee, Seung Hoon& Kang, Byung-jae& Kim, Wan Hee& Yun, Hui-suk& Kweon, Oh-kyeong. 2016. Comparison of Osteogenesis between Adipose-Derived Mesenchymal Stem Cells and Their Sheets on Poly-ε-Caprolactoneβ-Tricalcium Phosphate Composite Scaffolds in Canine Bone Defects. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Yongsun…[et al.]. Comparison of Osteogenesis between Adipose-Derived Mesenchymal Stem Cells and Their Sheets on Poly-ε-Caprolactoneβ-Tricalcium Phosphate Composite Scaffolds in Canine Bone Defects. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Yongsun& Lee, Seung Hoon& Kang, Byung-jae& Kim, Wan Hee& Yun, Hui-suk& Kweon, Oh-kyeong. Comparison of Osteogenesis between Adipose-Derived Mesenchymal Stem Cells and Their Sheets on Poly-ε-Caprolactoneβ-Tricalcium Phosphate Composite Scaffolds in Canine Bone Defects. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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