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Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy
المؤلفون المشاركون
Eljaszewicz, Andrzej
Dabrowska, Milena
Lipinska, Danuta
Grubczak, Kamil
Zbucka-Kretowska, Monika
Mrugacz, Grzegorz
Ratajczak, Mariusz Z.
Rusak, Malgorzata
Moniuszko, Marcin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-09
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Recently, murine hematopoietic progenitor stem cells (HSCs) and very small embryonic-like stem cells (VSELs) were demonstrated to express receptors for sex hormones including follicle-stimulating hormone (FSH).
This raised the question of whether FSH therapy at clinically applied doses can mobilize stem/progenitor cells in humans.
Here we assessed frequencies of VSELs (referred to as Lin−CD235a−CD45−CD133+ cells), HSPCs (referred to as Lin−CD235a−CD45+CD133+ cells), and endothelial progenitor cells (EPCs, identified as CD34+CD144+, CD34+CD133+, and CD34+CD309+CD133+ cells) in fifteen female patients subjected to the FSH therapy.
We demonstrated that FSH therapy resulted in statistically significant enhancement in peripheral blood (PB) number of both VSELs and HSPCs.
In contrast, the pattern of responses of EPCs delineated by different cell phenotypes was not uniform and we did not observe any significant changes in EPC numbers following hormone therapy.
Our data indicate that FSH therapy mobilizes VSELs and HSPCs into peripheral blood that on one hand supports their developmental origin from germ lineage, and on the other hand FSH can become a promising candidate tool for mobilizing HSCs and stem cells with VSEL phenotype in clinical settings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zbucka-Kretowska, Monika& Eljaszewicz, Andrzej& Lipinska, Danuta& Grubczak, Kamil& Rusak, Malgorzata& Mrugacz, Grzegorz…[et al.]. 2015. Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117280
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zbucka-Kretowska, Monika…[et al.]. Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1117280
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zbucka-Kretowska, Monika& Eljaszewicz, Andrzej& Lipinska, Danuta& Grubczak, Kamil& Rusak, Malgorzata& Mrugacz, Grzegorz…[et al.]. Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117280
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117280
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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