Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy
Joint Authors
Eljaszewicz, Andrzej
Dabrowska, Milena
Lipinska, Danuta
Grubczak, Kamil
Zbucka-Kretowska, Monika
Mrugacz, Grzegorz
Ratajczak, Mariusz Z.
Rusak, Malgorzata
Moniuszko, Marcin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Recently, murine hematopoietic progenitor stem cells (HSCs) and very small embryonic-like stem cells (VSELs) were demonstrated to express receptors for sex hormones including follicle-stimulating hormone (FSH).
This raised the question of whether FSH therapy at clinically applied doses can mobilize stem/progenitor cells in humans.
Here we assessed frequencies of VSELs (referred to as Lin−CD235a−CD45−CD133+ cells), HSPCs (referred to as Lin−CD235a−CD45+CD133+ cells), and endothelial progenitor cells (EPCs, identified as CD34+CD144+, CD34+CD133+, and CD34+CD309+CD133+ cells) in fifteen female patients subjected to the FSH therapy.
We demonstrated that FSH therapy resulted in statistically significant enhancement in peripheral blood (PB) number of both VSELs and HSPCs.
In contrast, the pattern of responses of EPCs delineated by different cell phenotypes was not uniform and we did not observe any significant changes in EPC numbers following hormone therapy.
Our data indicate that FSH therapy mobilizes VSELs and HSPCs into peripheral blood that on one hand supports their developmental origin from germ lineage, and on the other hand FSH can become a promising candidate tool for mobilizing HSCs and stem cells with VSEL phenotype in clinical settings.
American Psychological Association (APA)
Zbucka-Kretowska, Monika& Eljaszewicz, Andrzej& Lipinska, Danuta& Grubczak, Kamil& Rusak, Malgorzata& Mrugacz, Grzegorz…[et al.]. 2015. Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117280
Modern Language Association (MLA)
Zbucka-Kretowska, Monika…[et al.]. Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1117280
American Medical Association (AMA)
Zbucka-Kretowska, Monika& Eljaszewicz, Andrzej& Lipinska, Danuta& Grubczak, Kamil& Rusak, Malgorzata& Mrugacz, Grzegorz…[et al.]. Effective Mobilization of Very Small Embryonic-Like Stem Cells and Hematopoietic StemProgenitor Cells but Not Endothelial Progenitor Cells by Follicle-Stimulating Hormone Therapy. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117280