Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy
المؤلفون المشاركون
Wang, Liming
Zhang, Yu
Li, Hongtao
Hong, Jingxin
Chen, Xiaobo
Li, Ming
Wang, Jiangang
Liu, Yongjun
Wu, Mingyuan
Bai, Wen
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-06
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Juvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17.
It may cause sequelae due to lack of effective treatment.
The goal of this study is to explore the therapeutic effect of umbilical cord mesenchymal stem cells (UC-MSCs) for JIA.
Ten JIA patients were treated with UC-MSCs and received second infusion three months later.
Some key values such as 28-joint disease activity score (DAS28), TNF-α, IL-6, and regulatory T cells (Tregs) were evaluated.
Data were collected at 3 months and 6 months after first treatment.
DAS28 score of 10 patients was between 2.6 and 3.2 at three months after infusion.
WBC, ESR, and CRP were significantly decreased while Tregs were remarkably increased and IL-6 and TNF-α were declined.
Similar changes of above values were found after 6 months.
At the same time, the amount of NSAIDS and steroid usage in patients was reduced.
However, no significant changes were found comparing the data from 3 and 6 months.
These results suggest that UC-MSCs can reduce inflammatory cytokines, improve immune network effects, adjust immune tolerance, and effectively alleviate the symptoms and they might provide a safe and novel approach for JIA treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Liming& Zhang, Yu& Li, Hongtao& Hong, Jingxin& Chen, Xiaobo& Li, Ming…[et al.]. 2015. Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Liming…[et al.]. Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1117380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Liming& Zhang, Yu& Li, Hongtao& Hong, Jingxin& Chen, Xiaobo& Li, Ming…[et al.]. Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر