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Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy
Joint Authors
Wang, Liming
Zhang, Yu
Li, Hongtao
Hong, Jingxin
Chen, Xiaobo
Li, Ming
Wang, Jiangang
Liu, Yongjun
Wu, Mingyuan
Bai, Wen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Juvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17.
It may cause sequelae due to lack of effective treatment.
The goal of this study is to explore the therapeutic effect of umbilical cord mesenchymal stem cells (UC-MSCs) for JIA.
Ten JIA patients were treated with UC-MSCs and received second infusion three months later.
Some key values such as 28-joint disease activity score (DAS28), TNF-α, IL-6, and regulatory T cells (Tregs) were evaluated.
Data were collected at 3 months and 6 months after first treatment.
DAS28 score of 10 patients was between 2.6 and 3.2 at three months after infusion.
WBC, ESR, and CRP were significantly decreased while Tregs were remarkably increased and IL-6 and TNF-α were declined.
Similar changes of above values were found after 6 months.
At the same time, the amount of NSAIDS and steroid usage in patients was reduced.
However, no significant changes were found comparing the data from 3 and 6 months.
These results suggest that UC-MSCs can reduce inflammatory cytokines, improve immune network effects, adjust immune tolerance, and effectively alleviate the symptoms and they might provide a safe and novel approach for JIA treatment.
American Psychological Association (APA)
Wang, Liming& Zhang, Yu& Li, Hongtao& Hong, Jingxin& Chen, Xiaobo& Li, Ming…[et al.]. 2015. Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117380
Modern Language Association (MLA)
Wang, Liming…[et al.]. Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1117380
American Medical Association (AMA)
Wang, Liming& Zhang, Yu& Li, Hongtao& Hong, Jingxin& Chen, Xiaobo& Li, Ming…[et al.]. Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117380