Identification of Malignancy-Associated Changes in Histologically Normal Tumor-Adjacent Epithelium of Patients with HPV-Positive Oropharyngeal Cancer

المؤلفون المشاركون

Jabalee, James
Carraro, Anita
Ng, Tony
Prisman, Eitan
Guillaud, Martial
Garnis, Cathie

المصدر

Analytical Cellular Pathology

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-03-11

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

The incidence of HPV-positive oropharyngeal cancer (HPV+ OPC) is increasing, thus presenting new challenges for disease detection and management.

Noninvasive methods involving brush biopsies of diseased tissues were recently reported as insufficient for tumor detection in HPV+ OPC patients, likely due to differences between the site of tumor initiation at the base of involuted crypts and the site of brush biopsy at the crypt surface.

We hypothesized that histologically normal surface epithelial cells in the oropharynx contain changes in nuclear morphology that arise due to tumor proximity.

We analyzed the nuclear phenotype of matched tumor, tumor-adjacent normal, and contralateral normal tissues from biopsies of nine HPV+ OPC patients.

Measurements of 89 nuclear features were used to train a random forest-based classifier to discriminate between normal and tumor nuclei.

We then extracted voting scores from the trained classifier, which classify nuclei on a continuous scale from zero (“normal-like”) to one (“tumor-like”).

In each case, the average score of the adjacent normal nuclei was intermediate between the tumor and contralateral normal nuclei.

These results provide evidence for the existence of phenotypic changes in histologically normal, tumor-adjacent surface epithelial cells, which could be used as brush biopsy-based biomarkers for HPV+ OPC detection.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Jabalee, James& Carraro, Anita& Ng, Tony& Prisman, Eitan& Garnis, Cathie& Guillaud, Martial. 2018. Identification of Malignancy-Associated Changes in Histologically Normal Tumor-Adjacent Epithelium of Patients with HPV-Positive Oropharyngeal Cancer. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117424

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Jabalee, James…[et al.]. Identification of Malignancy-Associated Changes in Histologically Normal Tumor-Adjacent Epithelium of Patients with HPV-Positive Oropharyngeal Cancer. Analytical Cellular Pathology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1117424

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Jabalee, James& Carraro, Anita& Ng, Tony& Prisman, Eitan& Garnis, Cathie& Guillaud, Martial. Identification of Malignancy-Associated Changes in Histologically Normal Tumor-Adjacent Epithelium of Patients with HPV-Positive Oropharyngeal Cancer. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117424

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1117424