Effects of Mechanical Stretch on Cell Proliferation and Matrix Formation of Mesenchymal Stem Cell and Anterior Cruciate Ligament Fibroblast
المؤلفون المشاركون
Fan, Jiabing
Qu, Ling
Li, Hongguo
Liu, Xincheng
Zhu, Rui
Xue, Yingsen
Sun, Liguo
Fan, Hongbin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-25
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Mesenchymal stem cells (MSCs) and fibroblasts are two major seed cells for ligament tissue engineering.
To understand the effects of mechanical stimulation on these cells and to develop effective approaches for cell therapy, it is necessary to investigate the biological effects of various mechanical loading conditions on cells.
In this study, fibroblasts and MSCs were tested and compared under a novel Uniflex/Bioflex culture system that might mimic mechanical strain in ligament tissue.
The cells were uniaxially or radially stretched with different strains (5%, 10%, and 15%) at 0.1, 0.5, and 1.0 Hz.
The cell proliferation and collagen production were compared to find the optimal parameters.
The results indicated that uniaxial stretch (15% at 0.5 Hz; 10% at 1.0 Hz) showed positive effects on fibroblast.
The uniaxial strains (5%, 10%, and 15%) at 0.5 Hz and 10% strain at 1.0 Hz were favorable for MSCs.
Radial strain did not have significant effect on fibroblast.
On the contrary, the radial strains (5%, 10%, and 15%) at 0.1 Hz had positive effects on MSCs.
This study suggested that fibroblasts and MSCs had their own appropriate mechanical stimulatory parameters.
These specific parameters potentially provide fundamental knowledge for future cell-based ligament regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Liguo& Qu, Ling& Zhu, Rui& Li, Hongguo& Xue, Yingsen& Liu, Xincheng…[et al.]. 2016. Effects of Mechanical Stretch on Cell Proliferation and Matrix Formation of Mesenchymal Stem Cell and Anterior Cruciate Ligament Fibroblast. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117482
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Liguo…[et al.]. Effects of Mechanical Stretch on Cell Proliferation and Matrix Formation of Mesenchymal Stem Cell and Anterior Cruciate Ligament Fibroblast. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117482
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Liguo& Qu, Ling& Zhu, Rui& Li, Hongguo& Xue, Yingsen& Liu, Xincheng…[et al.]. Effects of Mechanical Stretch on Cell Proliferation and Matrix Formation of Mesenchymal Stem Cell and Anterior Cruciate Ligament Fibroblast. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117482
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117482
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر