Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features
المؤلفون المشاركون
Franin, Ivan
Klarić, Marko
Ferrari, Ani Mihaljević
Karnjuš-Begonja, Ružica
Eminović, Senija
Ostojić, Damjana Verša
Vrdoljak-Mozetič, Danijela
Babarović, Emina
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Adult granulosa cell tumors (AGCTs) represent 2%–5% of all ovarian malignancies.
The aim of this study was to analyze clinical and pathohistological parameters and their impact on recurrence, overall, and disease-free survival in FIGO stage I AGCT patients.
Methods.
The tumor specimens analyzed in this retrospective study were obtained from a total of 36 patients with diagnosis of ovarian AGCT surgically treated at the Department of Gynecology, Rijeka University Hospital Centre, between 1994 and 2012.
Clinical, pathological, and follow-up data were collected.
Results.
The mean age at diagnosis was 54.5 years with a range of 24–84.
The majority of the patients, 30 (83%), were in FIGO stage IA, 3 (8%) in stage IC1, 1 (3%) in stage IC2, and 2 (6%) in stage IC3.
During follow-up period (median 117.5 months, range 26–276), recurrence occurred in 4 patients (12%) with 2 deaths of the disease recorded.
In univariate analysis, the 5-year survival rates were significantly shorter in patients with FIGO substage IC (p=0.019), with positive LVSI (p=0.022), with presence of necrosis (p=0.040), and with hemorrhage (p=0.017).
In univariate analysis, the 5-year disease-free survival rates were significantly shorter in patients treated with fertility surgery (p=0.004), with diffuse growth pattern (p=0.012), with moderate and severe nuclear atypia (p=0.032), and with presence of hemorrhage (p=0.022).
FIGO substage IC proved to be independent predictor for recurrence (OR = 16.87, p=0.015, and OR = 23.49, p=0.023, resp.) and disease-free survival (p=0.0002; HR 20.84, p=0.02) at the uni- and multivariate analyses.
Conclusions.
FIGO substage IC is predictive of recurrence and disease-free survival in patients with early-stage AGCTs.
LVSI, presence of necrosis and hemorrhage, diffuse growth pattern, and nuclear atypia in AGCTs seem to be associated with overall and disease-free survival, so these pathological features should be taken into consideration when managing patients with AGCT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Babarović, Emina& Franin, Ivan& Klarić, Marko& Ferrari, Ani Mihaljević& Karnjuš-Begonja, Ružica& Eminović, Senija…[et al.]. 2018. Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1117585
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Babarović, Emina…[et al.]. Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features. Analytical Cellular Pathology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1117585
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Babarović, Emina& Franin, Ivan& Klarić, Marko& Ferrari, Ani Mihaljević& Karnjuš-Begonja, Ružica& Eminović, Senija…[et al.]. Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1117585
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117585
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر