Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features
Joint Authors
Franin, Ivan
Klarić, Marko
Ferrari, Ani Mihaljević
Karnjuš-Begonja, Ružica
Eminović, Senija
Ostojić, Damjana Verša
Vrdoljak-Mozetič, Danijela
Babarović, Emina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Adult granulosa cell tumors (AGCTs) represent 2%–5% of all ovarian malignancies.
The aim of this study was to analyze clinical and pathohistological parameters and their impact on recurrence, overall, and disease-free survival in FIGO stage I AGCT patients.
Methods.
The tumor specimens analyzed in this retrospective study were obtained from a total of 36 patients with diagnosis of ovarian AGCT surgically treated at the Department of Gynecology, Rijeka University Hospital Centre, between 1994 and 2012.
Clinical, pathological, and follow-up data were collected.
Results.
The mean age at diagnosis was 54.5 years with a range of 24–84.
The majority of the patients, 30 (83%), were in FIGO stage IA, 3 (8%) in stage IC1, 1 (3%) in stage IC2, and 2 (6%) in stage IC3.
During follow-up period (median 117.5 months, range 26–276), recurrence occurred in 4 patients (12%) with 2 deaths of the disease recorded.
In univariate analysis, the 5-year survival rates were significantly shorter in patients with FIGO substage IC (p=0.019), with positive LVSI (p=0.022), with presence of necrosis (p=0.040), and with hemorrhage (p=0.017).
In univariate analysis, the 5-year disease-free survival rates were significantly shorter in patients treated with fertility surgery (p=0.004), with diffuse growth pattern (p=0.012), with moderate and severe nuclear atypia (p=0.032), and with presence of hemorrhage (p=0.022).
FIGO substage IC proved to be independent predictor for recurrence (OR = 16.87, p=0.015, and OR = 23.49, p=0.023, resp.) and disease-free survival (p=0.0002; HR 20.84, p=0.02) at the uni- and multivariate analyses.
Conclusions.
FIGO substage IC is predictive of recurrence and disease-free survival in patients with early-stage AGCTs.
LVSI, presence of necrosis and hemorrhage, diffuse growth pattern, and nuclear atypia in AGCTs seem to be associated with overall and disease-free survival, so these pathological features should be taken into consideration when managing patients with AGCT.
American Psychological Association (APA)
Babarović, Emina& Franin, Ivan& Klarić, Marko& Ferrari, Ani Mihaljević& Karnjuš-Begonja, Ružica& Eminović, Senija…[et al.]. 2018. Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1117585
Modern Language Association (MLA)
Babarović, Emina…[et al.]. Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features. Analytical Cellular Pathology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1117585
American Medical Association (AMA)
Babarović, Emina& Franin, Ivan& Klarić, Marko& Ferrari, Ani Mihaljević& Karnjuš-Begonja, Ružica& Eminović, Senija…[et al.]. Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1117585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117585