Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin
المؤلفون المشاركون
Marzouki, Mohamed Nejib
Debouki-Joudi, Saoussen
Mhirsi, Sonia
Mokni-Baizig, Nehla
Ammous-Boukhris, Nihel
Mhamdi, Hayet
Mokdad-Gargouri, Raja
Gritli, Saïd
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
The transcription factor Krüppel-like factor 6 (KLF6) regulates various cellular functions, such as metabolism, cell proliferation, and differentiation.
KLF6 plays a key role in the development and progression of multiple human cancers.
Methods.
Fifty primary biopsies and 10 normal nasopharyngeal mucosae were used to analyze by RT-QPCR the expression and the copy number of wtKLF6 and the spliced variants (KLF6-SV1, KLF6-SV2, and KLF6-SV3) in Tunisian patients with nasopharyngeal carcinoma.
The expression analysis of E-cadherin and cyclin D1 was conducted by RT-QPCR and Western blot, respectively.
Results.
The wtKLF6 was significantly downexpressed in tumors compared to normal tissues (p=0.0015), whereas KLF6-SV1 and KLF6-SV2 were overexpressed in tumors compared to wtKLF6 and KLF6-SV3 (p<0.0001).
Copy number variation was reduced in tumors compared to normal tissues (p=0.0071).
Interestingly, KLF6-SV1 is associated with the juvenile form (p=0.0003) which is more aggressive than the adult form of NPC.
Furthermore, the oncogenic variant KLF6-SV1 was overexpressed in tumors lacking the expression of E-cadherin (p=0.0022) suggesting its role in metastasis and tumor progression.
The wtKLF6 is associated negatively with cyclin D1 in tumor tissues (p=0.048).
Conclusion.
The wtKLF6 was downexpressed in contrast with the oncogenic variants.
Overexpression of KLF6-SV1 is associated with young patients, and loss of E-cadherin suggests that this variant correlated with the aggressiveness of NPC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Debouki-Joudi, Saoussen& Mhirsi, Sonia& Mokni-Baizig, Nehla& Ammous-Boukhris, Nihel& Mhamdi, Hayet& Gritli, Saïd…[et al.]. 2018. Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Debouki-Joudi, Saoussen…[et al.]. Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin. Analytical Cellular Pathology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1117607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Debouki-Joudi, Saoussen& Mhirsi, Sonia& Mokni-Baizig, Nehla& Ammous-Boukhris, Nihel& Mhamdi, Hayet& Gritli, Saïd…[et al.]. Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر