Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin
Joint Authors
Marzouki, Mohamed Nejib
Debouki-Joudi, Saoussen
Mhirsi, Sonia
Mokni-Baizig, Nehla
Ammous-Boukhris, Nihel
Mhamdi, Hayet
Mokdad-Gargouri, Raja
Gritli, Saïd
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
The transcription factor Krüppel-like factor 6 (KLF6) regulates various cellular functions, such as metabolism, cell proliferation, and differentiation.
KLF6 plays a key role in the development and progression of multiple human cancers.
Methods.
Fifty primary biopsies and 10 normal nasopharyngeal mucosae were used to analyze by RT-QPCR the expression and the copy number of wtKLF6 and the spliced variants (KLF6-SV1, KLF6-SV2, and KLF6-SV3) in Tunisian patients with nasopharyngeal carcinoma.
The expression analysis of E-cadherin and cyclin D1 was conducted by RT-QPCR and Western blot, respectively.
Results.
The wtKLF6 was significantly downexpressed in tumors compared to normal tissues (p=0.0015), whereas KLF6-SV1 and KLF6-SV2 were overexpressed in tumors compared to wtKLF6 and KLF6-SV3 (p<0.0001).
Copy number variation was reduced in tumors compared to normal tissues (p=0.0071).
Interestingly, KLF6-SV1 is associated with the juvenile form (p=0.0003) which is more aggressive than the adult form of NPC.
Furthermore, the oncogenic variant KLF6-SV1 was overexpressed in tumors lacking the expression of E-cadherin (p=0.0022) suggesting its role in metastasis and tumor progression.
The wtKLF6 is associated negatively with cyclin D1 in tumor tissues (p=0.048).
Conclusion.
The wtKLF6 was downexpressed in contrast with the oncogenic variants.
Overexpression of KLF6-SV1 is associated with young patients, and loss of E-cadherin suggests that this variant correlated with the aggressiveness of NPC.
American Psychological Association (APA)
Debouki-Joudi, Saoussen& Mhirsi, Sonia& Mokni-Baizig, Nehla& Ammous-Boukhris, Nihel& Mhamdi, Hayet& Gritli, Saïd…[et al.]. 2018. Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117607
Modern Language Association (MLA)
Debouki-Joudi, Saoussen…[et al.]. Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin. Analytical Cellular Pathology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1117607
American Medical Association (AMA)
Debouki-Joudi, Saoussen& Mhirsi, Sonia& Mokni-Baizig, Nehla& Ammous-Boukhris, Nihel& Mhamdi, Hayet& Gritli, Saïd…[et al.]. Overexpression of the Oncogenic Variant (KLF6-SV1) in Young NPC Patients and Correlation with Lack of E-Cadherin. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117607