Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma

المؤلفون المشاركون

Nicolazzo, Chiara
Gradilone, Angela
Colangelo, Luciano
Corsi, Alessandro
Sonato, Chiara
Raimondi, Cristina
Gazzaniga, Paola
Gianni, Walter
Gaudio, Eugenio
Carpino, Guido

المصدر

Analytical Cellular Pathology

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-4، 4ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-03-07

دولة النشر

مصر

عدد الصفحات

4

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied.

The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous dissemination; for this reason, we investigated, for the first time, the presence of circulating tumor cells (CTCs) in hemangiopericytoma patient by CellSearch® and SceenCell® devices.

Peripheral blood samples were drawn and processed by CellSearch, an EpCAM-dependent device, and ScreenCell®, a device size based.

We found nontypical CTCs by CellSearch system and the immunofluorescence analysis performed on CTCs isolate by ScreenCell demonstrated the presence of single CTCs and CTC clusters.

The molecular characterization of single CTCs and CTC clusters, using antibodies directed against EpCAM, CD34, cytokeratins (8, 18, and 19), and CD45, showed a great heterogeneity in CTC clusters.

We believe that the present study may open a new scenario in the rare tumors: the introduction of the liquid biopsy and the molecular characterization of circulating tumor cells could lead to personalized targeted treatments and also for rare tumors.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nicolazzo, Chiara& Colangelo, Luciano& Corsi, Alessandro& Carpino, Guido& Gradilone, Angela& Sonato, Chiara…[et al.]. 2018. Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1117610

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nicolazzo, Chiara…[et al.]. Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma. Analytical Cellular Pathology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1117610

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nicolazzo, Chiara& Colangelo, Luciano& Corsi, Alessandro& Carpino, Guido& Gradilone, Angela& Sonato, Chiara…[et al.]. Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1117610

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1117610