Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma
Joint Authors
Nicolazzo, Chiara
Gradilone, Angela
Colangelo, Luciano
Corsi, Alessandro
Sonato, Chiara
Raimondi, Cristina
Gazzaniga, Paola
Gianni, Walter
Gaudio, Eugenio
Carpino, Guido
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied.
The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous dissemination; for this reason, we investigated, for the first time, the presence of circulating tumor cells (CTCs) in hemangiopericytoma patient by CellSearch® and SceenCell® devices.
Peripheral blood samples were drawn and processed by CellSearch, an EpCAM-dependent device, and ScreenCell®, a device size based.
We found nontypical CTCs by CellSearch system and the immunofluorescence analysis performed on CTCs isolate by ScreenCell demonstrated the presence of single CTCs and CTC clusters.
The molecular characterization of single CTCs and CTC clusters, using antibodies directed against EpCAM, CD34, cytokeratins (8, 18, and 19), and CD45, showed a great heterogeneity in CTC clusters.
We believe that the present study may open a new scenario in the rare tumors: the introduction of the liquid biopsy and the molecular characterization of circulating tumor cells could lead to personalized targeted treatments and also for rare tumors.
American Psychological Association (APA)
Nicolazzo, Chiara& Colangelo, Luciano& Corsi, Alessandro& Carpino, Guido& Gradilone, Angela& Sonato, Chiara…[et al.]. 2018. Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1117610
Modern Language Association (MLA)
Nicolazzo, Chiara…[et al.]. Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma. Analytical Cellular Pathology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1117610
American Medical Association (AMA)
Nicolazzo, Chiara& Colangelo, Luciano& Corsi, Alessandro& Carpino, Guido& Gradilone, Angela& Sonato, Chiara…[et al.]. Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1117610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117610