Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma

الملخص EN

Introduction.

Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis.

Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer.

This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma.

Methods.

Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC).

Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level was measured using commercial ELISA kit.

Results.

The monocyte count of subjects in groups IVB and IVC was significantly higher compared to group I-IVA (707/μL versus 528/μL, p=0.022; 841/μL versus 528/μL, p=0.005).

Plasma levels of sP-selectin in group IVC were higher than group I-IVA (59.5 ng/mL versus 41.97 ng/mL, p=0.001) and group IVB (59.5 ng/mL versus 45.53 ng/mL, p=0.007).

In subjects with high monocyte count (>665/μL), there was moderate correlation between monocyte count and sP-selectin (r=0.436, p=0.022).

Conclusion.

Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages.

Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup.