Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma
Joint Authors
Rachman, Andhika
Komala, Adi Surya
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis.
Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer.
This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma.
Methods.
Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC).
Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level was measured using commercial ELISA kit.
Results.
The monocyte count of subjects in groups IVB and IVC was significantly higher compared to group I-IVA (707/μL versus 528/μL, p=0.022; 841/μL versus 528/μL, p=0.005).
Plasma levels of sP-selectin in group IVC were higher than group I-IVA (59.5 ng/mL versus 41.97 ng/mL, p=0.001) and group IVB (59.5 ng/mL versus 45.53 ng/mL, p=0.007).
In subjects with high monocyte count (>665/μL), there was moderate correlation between monocyte count and sP-selectin (r=0.436, p=0.022).
Conclusion.
Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages.
Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup.
American Psychological Association (APA)
Komala, Adi Surya& Rachman, Andhika. 2018. Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma. Advances in Hematology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1117738
Modern Language Association (MLA)
Komala, Adi Surya& Rachman, Andhika. Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma. Advances in Hematology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1117738
American Medical Association (AMA)
Komala, Adi Surya& Rachman, Andhika. Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma. Advances in Hematology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1117738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117738