Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations
المؤلفون المشاركون
Taylor, Jason R.
Chahla, Elie
Cheesman, Antonio
Mahon, Suzanne M.
Garrett, Robert W.
Bradenham , Ben P.
Schwartz, Theresa L.
Omran, Louay
Alkaade, Samer
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
Pancreatic adenocarcinoma is typically diagnosed in advanced stages resulting in a significant reduction in the number of patients who are candidates for surgical resection.
Although the majority of cases are believed to occur sporadically, about 10% show familial clustering and studies have identified an increased frequency of BRCA germline mutations.
The role of screening for pancreatic adenocarcinoma in these populations is unclear.
Our study aims to identify the abnormal pancreatic imaging findings in BRCA1 and BRCA2 mutation carriers.
Methods.
A retrospective review of patient medical records with known BRCA1 and BRCA2 mutations was conducted.
Data was collected and all available abdominal imaging studies were reviewed.
Results.
A total of 66 patients were identified, 36 with BRCA1 and 30 with BRCA2 mutations.
Only 20/66 (30%) had abdominal imaging (14 BRCA1 and 6 BRCA2 patients).
Of those patients with abdominal imaging, abnormal pancreatic imaging findings were detected in 7/20 (35%) cases.
Conclusion.
Our study shows a high incidence of abnormal pancreatic imaging findings in patients with BRCA genetic mutations (35%).
Larger studies are needed to further define the role of pancreatic cancer screening and the significance of abnormal imaging findings in BRCA1 and BRCA2 mutation carriers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chahla, Elie& Cheesman, Antonio& Mahon, Suzanne M.& Garrett, Robert W. & Bradenham , Ben P.& Schwartz, Theresa L.…[et al.]. 2016. Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. Scientifica،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117763
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chahla, Elie…[et al.]. Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. Scientifica No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1117763
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chahla, Elie& Cheesman, Antonio& Mahon, Suzanne M.& Garrett, Robert W. & Bradenham , Ben P.& Schwartz, Theresa L.…[et al.]. Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117763
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117763
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر