Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations
Joint Authors
Taylor, Jason R.
Chahla, Elie
Cheesman, Antonio
Mahon, Suzanne M.
Garrett, Robert W.
Bradenham , Ben P.
Schwartz, Theresa L.
Omran, Louay
Alkaade, Samer
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Pancreatic adenocarcinoma is typically diagnosed in advanced stages resulting in a significant reduction in the number of patients who are candidates for surgical resection.
Although the majority of cases are believed to occur sporadically, about 10% show familial clustering and studies have identified an increased frequency of BRCA germline mutations.
The role of screening for pancreatic adenocarcinoma in these populations is unclear.
Our study aims to identify the abnormal pancreatic imaging findings in BRCA1 and BRCA2 mutation carriers.
Methods.
A retrospective review of patient medical records with known BRCA1 and BRCA2 mutations was conducted.
Data was collected and all available abdominal imaging studies were reviewed.
Results.
A total of 66 patients were identified, 36 with BRCA1 and 30 with BRCA2 mutations.
Only 20/66 (30%) had abdominal imaging (14 BRCA1 and 6 BRCA2 patients).
Of those patients with abdominal imaging, abnormal pancreatic imaging findings were detected in 7/20 (35%) cases.
Conclusion.
Our study shows a high incidence of abnormal pancreatic imaging findings in patients with BRCA genetic mutations (35%).
Larger studies are needed to further define the role of pancreatic cancer screening and the significance of abnormal imaging findings in BRCA1 and BRCA2 mutation carriers.
American Psychological Association (APA)
Chahla, Elie& Cheesman, Antonio& Mahon, Suzanne M.& Garrett, Robert W. & Bradenham , Ben P.& Schwartz, Theresa L.…[et al.]. 2016. Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. Scientifica،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117763
Modern Language Association (MLA)
Chahla, Elie…[et al.]. Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. Scientifica No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1117763
American Medical Association (AMA)
Chahla, Elie& Cheesman, Antonio& Mahon, Suzanne M.& Garrett, Robert W. & Bradenham , Ben P.& Schwartz, Theresa L.…[et al.]. Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1117763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117763