D-Amino Acids in the Nervous and Endocrine Systems

المؤلفون المشاركون

Kiriyama, Yoshimitsu
Nochi, Hiromi

المصدر

Scientifica

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-12-08

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

Amino acids are important components for peptides and proteins and act as signal transmitters.

Only L-amino acids have been considered necessary in mammals, including humans.

However, diverse D-amino acids, such as D-serine, D-aspartate, D-alanine, and D-cysteine, are found in mammals.

Physiological roles of these D-amino acids not only in the nervous system but also in the endocrine system are being gradually revealed.

N-Methyl-D-aspartate (NMDA) receptors are associated with learning and memory.

D-Serine, D-aspartate, and D-alanine can all bind to NMDA receptors.

H2S generated from D-cysteine reduces disulfide bonds in receptors and potentiates their activity.

Aberrant receptor activity is related to diseases of the central nervous system (CNS), such as Alzheimer’s disease, amyotrophic lateral sclerosis, and schizophrenia.

Furthermore, D-amino acids are detected in parts of the endocrine system, such as the pineal gland, hypothalamus, pituitary gland, pancreas, adrenal gland, and testis.

D-Aspartate is being investigated for the regulation of hormone release from various endocrine organs.

Here we focused on recent findings regarding the synthesis and physiological functions of D-amino acids in the nervous and endocrine systems.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kiriyama, Yoshimitsu& Nochi, Hiromi. 2016. D-Amino Acids in the Nervous and Endocrine Systems. Scientifica،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117835

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kiriyama, Yoshimitsu& Nochi, Hiromi. D-Amino Acids in the Nervous and Endocrine Systems. Scientifica No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1117835

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kiriyama, Yoshimitsu& Nochi, Hiromi. D-Amino Acids in the Nervous and Endocrine Systems. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117835

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1117835