In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers
المؤلفون المشاركون
Ku, Xin
Xu, Yan
Cai, Chunlin
Yang, Yili
Cui, Long
Yan, Wei
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Liver metastasis is the most common form of metastatic colorectal cancers during the course of the disease.
The global change in protein abundance in liver metastatic colorectal cancers and its role in metastasis establishment have not been comprehensively analyzed.
In the present study, fresh-frozen tissue samples including normal colon/localized/liver metastatic CRCs from each recruited patient were analyzed by quantitative proteomics using a multiplexed TMT labeling strategy.
Around 5000 protein groups were quantified from all samples.
The proteomic profile of localized/metastatic CRCs varied greatly from that of normal colon tissues; differential proteins were mainly from extracellular regions and participate in immune activities, which is crucial for the chronic inflammation signaling pathways in the tumor microenvironment.
Further statistical analysis revealed 47 proteins exhibiting statistical significance between localized and metastatic CRCs, of which FILI1P1 and PLG were identified for the first time in proteomic data, which were highly associated with liver metastasis in CRCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ku, Xin& Xu, Yan& Cai, Chunlin& Yang, Yili& Cui, Long& Yan, Wei. 2019. In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ku, Xin…[et al.]. In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers. Analytical Cellular Pathology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1117877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ku, Xin& Xu, Yan& Cai, Chunlin& Yang, Yili& Cui, Long& Yan, Wei. In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر