In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers
Joint Authors
Ku, Xin
Xu, Yan
Cai, Chunlin
Yang, Yili
Cui, Long
Yan, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Liver metastasis is the most common form of metastatic colorectal cancers during the course of the disease.
The global change in protein abundance in liver metastatic colorectal cancers and its role in metastasis establishment have not been comprehensively analyzed.
In the present study, fresh-frozen tissue samples including normal colon/localized/liver metastatic CRCs from each recruited patient were analyzed by quantitative proteomics using a multiplexed TMT labeling strategy.
Around 5000 protein groups were quantified from all samples.
The proteomic profile of localized/metastatic CRCs varied greatly from that of normal colon tissues; differential proteins were mainly from extracellular regions and participate in immune activities, which is crucial for the chronic inflammation signaling pathways in the tumor microenvironment.
Further statistical analysis revealed 47 proteins exhibiting statistical significance between localized and metastatic CRCs, of which FILI1P1 and PLG were identified for the first time in proteomic data, which were highly associated with liver metastasis in CRCs.
American Psychological Association (APA)
Ku, Xin& Xu, Yan& Cai, Chunlin& Yang, Yili& Cui, Long& Yan, Wei. 2019. In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117877
Modern Language Association (MLA)
Ku, Xin…[et al.]. In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers. Analytical Cellular Pathology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1117877
American Medical Association (AMA)
Ku, Xin& Xu, Yan& Cai, Chunlin& Yang, Yili& Cui, Long& Yan, Wei. In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1117877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117877