Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats
المؤلفون المشاركون
Puttegowda, Venkatesh Dinnekere
Karki, Roopa
Goli, Divakar
Jha, Sajal kumar
Mudagal, Manjunatha Panduranga
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Pravastatin Sodium has a cholesterol lowering agent.
It has shorter half-life and undergoes first-pass metabolism.
Frequent dose is required in case of conventional dosage form.
The purpose of the study is to formulate and evaluate microcapsules containing Pravastatin Sodium by complex with cholestyramine resins coated with Eudragit RLPO and Eudragit RSPO polymers for achieving control release.
Complexation of drug on resin was carried out by batch method.
Microencapsulation was carried out by nonaqueous solvent evaporation method.
Pharmacokinetic studies were done by using rats.
The intermediate stability studies were carried out on the most satisfactory formulations.
FTIR, X-ray diffraction, and DSC spectra of drug, drug-resinates, and polymers revealed no chemical interaction.
The % DEE and % yield were observed for formulations of f1 to f7 that were varied from 97.1 ± 0.8 to 98.9 ± 0.5% and 95.0 ± 3.25 to 98.8 ± 7.1%, respectively.
Most satisfactory formulation, f6, showed drug release up to 72.6%.
No changes in % DEE and % CDR were observed after stability studies.
Microcapsules of f6 formulation achieved best performance regarding in vitro drug release and from pharmacokinetic evaluation mean residence time was found to be 6.3 h, thus indicated, Pravastatin Sodium microcapsules were released and absorbed slowly over a prolonged period of time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Puttegowda, Venkatesh Dinnekere& Karki, Roopa& Goli, Divakar& Jha, Sajal kumar& Mudagal, Manjunatha Panduranga. 2016. Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats. Scientifica،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117887
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Puttegowda, Venkatesh Dinnekere…[et al.]. Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats. Scientifica No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1117887
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Puttegowda, Venkatesh Dinnekere& Karki, Roopa& Goli, Divakar& Jha, Sajal kumar& Mudagal, Manjunatha Panduranga. Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117887
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117887
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر