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Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats
Joint Authors
Puttegowda, Venkatesh Dinnekere
Karki, Roopa
Goli, Divakar
Jha, Sajal kumar
Mudagal, Manjunatha Panduranga
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pravastatin Sodium has a cholesterol lowering agent.
It has shorter half-life and undergoes first-pass metabolism.
Frequent dose is required in case of conventional dosage form.
The purpose of the study is to formulate and evaluate microcapsules containing Pravastatin Sodium by complex with cholestyramine resins coated with Eudragit RLPO and Eudragit RSPO polymers for achieving control release.
Complexation of drug on resin was carried out by batch method.
Microencapsulation was carried out by nonaqueous solvent evaporation method.
Pharmacokinetic studies were done by using rats.
The intermediate stability studies were carried out on the most satisfactory formulations.
FTIR, X-ray diffraction, and DSC spectra of drug, drug-resinates, and polymers revealed no chemical interaction.
The % DEE and % yield were observed for formulations of f1 to f7 that were varied from 97.1 ± 0.8 to 98.9 ± 0.5% and 95.0 ± 3.25 to 98.8 ± 7.1%, respectively.
Most satisfactory formulation, f6, showed drug release up to 72.6%.
No changes in % DEE and % CDR were observed after stability studies.
Microcapsules of f6 formulation achieved best performance regarding in vitro drug release and from pharmacokinetic evaluation mean residence time was found to be 6.3 h, thus indicated, Pravastatin Sodium microcapsules were released and absorbed slowly over a prolonged period of time.
American Psychological Association (APA)
Puttegowda, Venkatesh Dinnekere& Karki, Roopa& Goli, Divakar& Jha, Sajal kumar& Mudagal, Manjunatha Panduranga. 2016. Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats. Scientifica،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117887
Modern Language Association (MLA)
Puttegowda, Venkatesh Dinnekere…[et al.]. Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats. Scientifica No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1117887
American Medical Association (AMA)
Puttegowda, Venkatesh Dinnekere& Karki, Roopa& Goli, Divakar& Jha, Sajal kumar& Mudagal, Manjunatha Panduranga. Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117887