Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats
المؤلفون المشاركون
Ragy, Merhan
Ali, Fatma
Ramzy, Maggie M.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In the brain, the heme oxygenase (HO) system has been reported to be very active and its modulation seems to play a crucial role in the pathophysiology of neurodegenerative disorders.
Hemin as HO-1 inducer has been shown to attenuate neuronal injury so the goal of this study was to assess the effect of hemin therapy on the acute stress and how it would modulate neurological outcome.
Thirty male albino rats were divided into three groups: control group and stressed group with six-hour water immersion restraint stress (WIRS) and stressed group, treated with hemin, in which each rat received a single intraperitoneal injection of hemin at a dose level of 50 mg/kg body weight at 12 hours before exposure to WIRS.
Stress hormones, oxidative stress markers, malondialdehyde (MDA), and total antioxidant capacity (TAC) were measured and expressions of neuroglobin and S100B mRNA in brain tissue were assayed.
Our results revealed that hemin significantly affects brain alterations induced by acute stress and this may be through increased expression of neuroglobin and through antioxidant effect.
Hemin decreased blood-brain barrier damage as it significantly decreased the expression of S100B.
These results suggest that hemin may be an effective therapy for being neuroprotective against acute stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ragy, Merhan& Ali, Fatma& Ramzy, Maggie M.. 2016. Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats. Scientifica،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117890
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ragy, Merhan…[et al.]. Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats. Scientifica No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1117890
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ragy, Merhan& Ali, Fatma& Ramzy, Maggie M.. Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117890
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117890
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر