Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats
Joint Authors
Ragy, Merhan
Ali, Fatma
Ramzy, Maggie M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the brain, the heme oxygenase (HO) system has been reported to be very active and its modulation seems to play a crucial role in the pathophysiology of neurodegenerative disorders.
Hemin as HO-1 inducer has been shown to attenuate neuronal injury so the goal of this study was to assess the effect of hemin therapy on the acute stress and how it would modulate neurological outcome.
Thirty male albino rats were divided into three groups: control group and stressed group with six-hour water immersion restraint stress (WIRS) and stressed group, treated with hemin, in which each rat received a single intraperitoneal injection of hemin at a dose level of 50 mg/kg body weight at 12 hours before exposure to WIRS.
Stress hormones, oxidative stress markers, malondialdehyde (MDA), and total antioxidant capacity (TAC) were measured and expressions of neuroglobin and S100B mRNA in brain tissue were assayed.
Our results revealed that hemin significantly affects brain alterations induced by acute stress and this may be through increased expression of neuroglobin and through antioxidant effect.
Hemin decreased blood-brain barrier damage as it significantly decreased the expression of S100B.
These results suggest that hemin may be an effective therapy for being neuroprotective against acute stress.
American Psychological Association (APA)
Ragy, Merhan& Ali, Fatma& Ramzy, Maggie M.. 2016. Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats. Scientifica،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117890
Modern Language Association (MLA)
Ragy, Merhan…[et al.]. Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats. Scientifica No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1117890
American Medical Association (AMA)
Ragy, Merhan& Ali, Fatma& Ramzy, Maggie M.. Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117890