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Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation
المؤلفون المشاركون
Sack, Ulrich
Mai, Kristin
Boldt, Andreas
Hau, Hans-Michael
Kirschfink, Michael
Schiekofer, Stephan
Keller, Frieder
Beige, Joachim
Rasche, Franz Maximilian
Giannis, Athanassios
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Chronic or intercurrent alterations of the immune system in patients with end-stage renal disease (CKD) and intermittent hemodialysis (CKD5D, HD) have been attributed to an acute rejection of renal allograft.
Methods.
Leukocyte subsets in flow cytometry, complement activation, and concentrations of TGFβ, sCD30 (ELISA), and interleukins (CBA) of fifteen patients eligible for renal transplantation were analyzed before, during, and after a regular HD.
Results.
Before HD, the median proportion of CD8+ effector cells, CD8+ CCR5+ effector cells, and HLA-DR+ regulatory T cells as well as the median concentration of soluble CD30 increased and naive CD8+ T cells decreased.
During HD, there was a significant decrease in CD4- CD8- T cells (p<0.001) and an increase in CD25+ T cells (p=0.026), sCD30 (p<0.001), HLA-DR+ regulatory T cells (p=0.005), and regulatory T cells (p=0.003).
TGFβ and sCD30 increased significantly over time.
The activity of the classical complement pathway started to slightly increase after the first hour of HD and lasted until fifteen minutes after finishing dialysis.
The decrease in the functional activity of the alternative pathway was only transient and was followed by a significant increase within 15 minutes after finishing the treatment.
Conclusion.
HD might interact with the allograft outcome by influencing T cell subsets and activation of the complement system in a biphasic course.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mai, Kristin& Boldt, Andreas& Hau, Hans-Michael& Kirschfink, Michael& Schiekofer, Stephan& Keller, Frieder…[et al.]. 2019. Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1117894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mai, Kristin…[et al.]. Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation. Analytical Cellular Pathology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1117894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mai, Kristin& Boldt, Andreas& Hau, Hans-Michael& Kirschfink, Michael& Schiekofer, Stephan& Keller, Frieder…[et al.]. Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1117894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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