Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation
Joint Authors
Sack, Ulrich
Mai, Kristin
Boldt, Andreas
Hau, Hans-Michael
Kirschfink, Michael
Schiekofer, Stephan
Keller, Frieder
Beige, Joachim
Rasche, Franz Maximilian
Giannis, Athanassios
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Chronic or intercurrent alterations of the immune system in patients with end-stage renal disease (CKD) and intermittent hemodialysis (CKD5D, HD) have been attributed to an acute rejection of renal allograft.
Methods.
Leukocyte subsets in flow cytometry, complement activation, and concentrations of TGFβ, sCD30 (ELISA), and interleukins (CBA) of fifteen patients eligible for renal transplantation were analyzed before, during, and after a regular HD.
Results.
Before HD, the median proportion of CD8+ effector cells, CD8+ CCR5+ effector cells, and HLA-DR+ regulatory T cells as well as the median concentration of soluble CD30 increased and naive CD8+ T cells decreased.
During HD, there was a significant decrease in CD4- CD8- T cells (p<0.001) and an increase in CD25+ T cells (p=0.026), sCD30 (p<0.001), HLA-DR+ regulatory T cells (p=0.005), and regulatory T cells (p=0.003).
TGFβ and sCD30 increased significantly over time.
The activity of the classical complement pathway started to slightly increase after the first hour of HD and lasted until fifteen minutes after finishing dialysis.
The decrease in the functional activity of the alternative pathway was only transient and was followed by a significant increase within 15 minutes after finishing the treatment.
Conclusion.
HD might interact with the allograft outcome by influencing T cell subsets and activation of the complement system in a biphasic course.
American Psychological Association (APA)
Mai, Kristin& Boldt, Andreas& Hau, Hans-Michael& Kirschfink, Michael& Schiekofer, Stephan& Keller, Frieder…[et al.]. 2019. Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation. Analytical Cellular Pathology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1117894
Modern Language Association (MLA)
Mai, Kristin…[et al.]. Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation. Analytical Cellular Pathology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1117894
American Medical Association (AMA)
Mai, Kristin& Boldt, Andreas& Hau, Hans-Michael& Kirschfink, Michael& Schiekofer, Stephan& Keller, Frieder…[et al.]. Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation. Analytical Cellular Pathology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1117894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117894