![](/images/graphics-bg.png)
Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study
المؤلفون المشاركون
Voros, Dionysios
Polydorou, A.
Kontis, Elissaios
Vezakis, Antonios
Fragulidis, Georgios
Drakopoulou, Stamatoula
Pantiora, Eirini
Karandrea, Despoina
Aravidou, Eftychia
Argyra, Erifili
Kondi-Pafiti, A.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction and Aim.
With the implementation of multimodal analgesia regimens, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are often administered for optimal pain control and reduction of opioid use.
The aim of the study was to examine the effects of lornoxicam, a NSAID, on anastomotic healing employing an animal model.
Materials and Methods.
A total of 28 Wistar rats were randomly assigned in two groups.
All animals underwent ascending colonic transection followed by an end-to-end hand sewn anastomosis.
Group 1 received intraperitoneally lornoxicam before and daily after surgery.
Group 2 received intraperitoneally an equal volume of placebo.
Half of the animals in each group were euthanized on the 3rd pod and the remaining on the 7th pod.
Macro- and microscopic indicators of anastomotic healing were compared using a two-tailed Fisher exact test.
Results.
The lornoxicam group significantly decreased fibroblast in growth and reepithelization of the mucosa at the anastomotic site on the 3rd pod and significantly increased occurrence of deep reaching defects, necrosis, and microabscess on the 7th pod.
Conclusion.
Lornoxicam administration during the perioperative period adversely affects histologic parameters of intestinal anastomotic healing.
These effects of lornoxicam administration were not found to induce significant increase of anastomotic dehiscence in the rat model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Drakopoulou, Stamatoula& Kontis, Elissaios& Pantiora, Eirini& Vezakis, Antonios& Karandrea, Despoina& Aravidou, Eftychia…[et al.]. 2016. Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study. Surgery Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1118446
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Drakopoulou, Stamatoula…[et al.]. Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study. Surgery Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1118446
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Drakopoulou, Stamatoula& Kontis, Elissaios& Pantiora, Eirini& Vezakis, Antonios& Karandrea, Despoina& Aravidou, Eftychia…[et al.]. Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study. Surgery Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1118446
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1118446
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)