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Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study
Joint Authors
Voros, Dionysios
Polydorou, A.
Kontis, Elissaios
Vezakis, Antonios
Fragulidis, Georgios
Drakopoulou, Stamatoula
Pantiora, Eirini
Karandrea, Despoina
Aravidou, Eftychia
Argyra, Erifili
Kondi-Pafiti, A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction and Aim.
With the implementation of multimodal analgesia regimens, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are often administered for optimal pain control and reduction of opioid use.
The aim of the study was to examine the effects of lornoxicam, a NSAID, on anastomotic healing employing an animal model.
Materials and Methods.
A total of 28 Wistar rats were randomly assigned in two groups.
All animals underwent ascending colonic transection followed by an end-to-end hand sewn anastomosis.
Group 1 received intraperitoneally lornoxicam before and daily after surgery.
Group 2 received intraperitoneally an equal volume of placebo.
Half of the animals in each group were euthanized on the 3rd pod and the remaining on the 7th pod.
Macro- and microscopic indicators of anastomotic healing were compared using a two-tailed Fisher exact test.
Results.
The lornoxicam group significantly decreased fibroblast in growth and reepithelization of the mucosa at the anastomotic site on the 3rd pod and significantly increased occurrence of deep reaching defects, necrosis, and microabscess on the 7th pod.
Conclusion.
Lornoxicam administration during the perioperative period adversely affects histologic parameters of intestinal anastomotic healing.
These effects of lornoxicam administration were not found to induce significant increase of anastomotic dehiscence in the rat model.
American Psychological Association (APA)
Drakopoulou, Stamatoula& Kontis, Elissaios& Pantiora, Eirini& Vezakis, Antonios& Karandrea, Despoina& Aravidou, Eftychia…[et al.]. 2016. Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study. Surgery Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1118446
Modern Language Association (MLA)
Drakopoulou, Stamatoula…[et al.]. Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study. Surgery Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1118446
American Medical Association (AMA)
Drakopoulou, Stamatoula& Kontis, Elissaios& Pantiora, Eirini& Vezakis, Antonios& Karandrea, Despoina& Aravidou, Eftychia…[et al.]. Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study. Surgery Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1118446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1118446