Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate

المؤلفون المشاركون

Kuznietsova, Halyna M.
Kotlyar, Iryna P.
Rybalchenko, Volodymyr K.
Yena, Maryna S.
Ogloblya, Olexandr V.

المصدر

The Scientific World Journal

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-12-22

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب

الملخص EN

In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model.

Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative colitis (UC) model was aimed to be discovered.

The anti-inflammatory effects of MI-1 (2.7 mg/kg daily) compared to reference drug Prednisolone (0.7 mg/kg daily) after 14-day usage were evaluated on macro- and light microscopy levels and expressed in 21-grade scale.

Redox status of bowel mucosa was also estimated.

It was shown that in UC group the grade of total injury (GTI) was equal to 9.6 (GTIcontrol=0).

Increase of malonic dialdehyde (MDA) by 89% and protein carbonyl groups (PCG) by 60% and decrease of superoxide dismutase (SOD) by 40% were also observed.

Prednisolone decreased GTI to 3 and leveled SOD activity, but MDA and PCG remained higher than control ones by 52% and 42%, respectively.

MI-1 restored colon mucosa integrity and decreased mucosa inflammation down to GTI = 0.5 and leveled PCG and SOD.

Thus, MI-1 possessed anti-inflammatory properties, which were more expressed that Prednisolone ones, as well as normalized mucosa redox balance, and so has a prospect for correction of inflammatory processes.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kuznietsova, Halyna M.& Yena, Maryna S.& Kotlyar, Iryna P.& Ogloblya, Olexandr V.& Rybalchenko, Volodymyr K.. 2016. Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1120336

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kuznietsova, Halyna M.…[et al.]. Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate. The Scientific World Journal No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1120336

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kuznietsova, Halyna M.& Yena, Maryna S.& Kotlyar, Iryna P.& Ogloblya, Olexandr V.& Rybalchenko, Volodymyr K.. Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1120336

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1120336