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Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate
Joint Authors
Kuznietsova, Halyna M.
Kotlyar, Iryna P.
Rybalchenko, Volodymyr K.
Yena, Maryna S.
Ogloblya, Olexandr V.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model.
Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative colitis (UC) model was aimed to be discovered.
The anti-inflammatory effects of MI-1 (2.7 mg/kg daily) compared to reference drug Prednisolone (0.7 mg/kg daily) after 14-day usage were evaluated on macro- and light microscopy levels and expressed in 21-grade scale.
Redox status of bowel mucosa was also estimated.
It was shown that in UC group the grade of total injury (GTI) was equal to 9.6 (GTIcontrol=0).
Increase of malonic dialdehyde (MDA) by 89% and protein carbonyl groups (PCG) by 60% and decrease of superoxide dismutase (SOD) by 40% were also observed.
Prednisolone decreased GTI to 3 and leveled SOD activity, but MDA and PCG remained higher than control ones by 52% and 42%, respectively.
MI-1 restored colon mucosa integrity and decreased mucosa inflammation down to GTI = 0.5 and leveled PCG and SOD.
Thus, MI-1 possessed anti-inflammatory properties, which were more expressed that Prednisolone ones, as well as normalized mucosa redox balance, and so has a prospect for correction of inflammatory processes.
American Psychological Association (APA)
Kuznietsova, Halyna M.& Yena, Maryna S.& Kotlyar, Iryna P.& Ogloblya, Olexandr V.& Rybalchenko, Volodymyr K.. 2016. Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1120336
Modern Language Association (MLA)
Kuznietsova, Halyna M.…[et al.]. Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate. The Scientific World Journal No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1120336
American Medical Association (AMA)
Kuznietsova, Halyna M.& Yena, Maryna S.& Kotlyar, Iryna P.& Ogloblya, Olexandr V.& Rybalchenko, Volodymyr K.. Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1120336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1120336