Punica granatum L. (Pomegranate)‎ Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model

المؤلفون المشاركون

Oliveira, L. D.
Aparecida Procópio Gomes, Livia
Alves Figueiredo, Lívia Mara
Luiza do Rosário Palma, Ana
Corrêa Geraldo, Barbara Maria
Isler Castro, Kelly Cristine
Ruano de Oliveira Fugisaki, Luciana
Jorge, Antônio Olavo Cardoso
Junqueira, Juliana Campos

المصدر

The Scientific World Journal

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-09-07

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب

الملخص EN

Due to the increase of bacterial resistance, medicinal alternatives are being explored.

Punica granatum L.

is an effective herbal extract with broad spectrum of action and bactericidal, antifungal, anthelmintic potential and being able to modulate the immune response.

The aim was to evaluate the antimicrobial activity of pomegranate glycolic extract (PGE) against the periodontal pathogen Porphyromonas gingivalis by using Galleria mellonella as in vivo model.

Fifteen larvae were used per group.

Injection of high concentration (200, 100, and 25 mg/mL) of PGE showed a toxic effect, leading them to death.

A suspension of P.

gingivalis (106 cells/mL) was inoculated in the left last proleg and PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) were injected into the right proleg.

The larvae were then kept at 37°C under the dark.

Injection of PGE at any dose statistically improved larvae survival rates.

The data were analysed (log-rank test, Mantel-Cox, P < 0.05 ) and showed that all concentrations of PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) presented higher larval survival rates, with significant statistical difference in relation to control group (P.

gingivalis).

In conclusion, the PGE had antimicrobial action against P.

gingivalis in vivo model using G.

mellonella.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Aparecida Procópio Gomes, Livia& Alves Figueiredo, Lívia Mara& Luiza do Rosário Palma, Ana& Corrêa Geraldo, Barbara Maria& Isler Castro, Kelly Cristine& Ruano de Oliveira Fugisaki, Luciana…[et al.]. 2016. Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1120626

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Aparecida Procópio Gomes, Livia…[et al.]. Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model. The Scientific World Journal No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1120626

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Aparecida Procópio Gomes, Livia& Alves Figueiredo, Lívia Mara& Luiza do Rosário Palma, Ana& Corrêa Geraldo, Barbara Maria& Isler Castro, Kelly Cristine& Ruano de Oliveira Fugisaki, Luciana…[et al.]. Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1120626

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1120626