Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model
Joint Authors
Oliveira, L. D.
Aparecida Procópio Gomes, Livia
Alves Figueiredo, Lívia Mara
Luiza do Rosário Palma, Ana
Corrêa Geraldo, Barbara Maria
Isler Castro, Kelly Cristine
Ruano de Oliveira Fugisaki, Luciana
Jorge, Antônio Olavo Cardoso
Junqueira, Juliana Campos
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Due to the increase of bacterial resistance, medicinal alternatives are being explored.
Punica granatum L.
is an effective herbal extract with broad spectrum of action and bactericidal, antifungal, anthelmintic potential and being able to modulate the immune response.
The aim was to evaluate the antimicrobial activity of pomegranate glycolic extract (PGE) against the periodontal pathogen Porphyromonas gingivalis by using Galleria mellonella as in vivo model.
Fifteen larvae were used per group.
Injection of high concentration (200, 100, and 25 mg/mL) of PGE showed a toxic effect, leading them to death.
A suspension of P.
gingivalis (106 cells/mL) was inoculated in the left last proleg and PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) were injected into the right proleg.
The larvae were then kept at 37°C under the dark.
Injection of PGE at any dose statistically improved larvae survival rates.
The data were analysed (log-rank test, Mantel-Cox, P < 0.05 ) and showed that all concentrations of PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) presented higher larval survival rates, with significant statistical difference in relation to control group (P.
gingivalis).
In conclusion, the PGE had antimicrobial action against P.
gingivalis in vivo model using G.
mellonella.
American Psychological Association (APA)
Aparecida Procópio Gomes, Livia& Alves Figueiredo, Lívia Mara& Luiza do Rosário Palma, Ana& Corrêa Geraldo, Barbara Maria& Isler Castro, Kelly Cristine& Ruano de Oliveira Fugisaki, Luciana…[et al.]. 2016. Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1120626
Modern Language Association (MLA)
Aparecida Procópio Gomes, Livia…[et al.]. Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model. The Scientific World Journal No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1120626
American Medical Association (AMA)
Aparecida Procópio Gomes, Livia& Alves Figueiredo, Lívia Mara& Luiza do Rosário Palma, Ana& Corrêa Geraldo, Barbara Maria& Isler Castro, Kelly Cristine& Ruano de Oliveira Fugisaki, Luciana…[et al.]. Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1120626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1120626